Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3314934 | Journal of Hepatology | 2006 | 6 Pages |
Abstract
Cell proliferation decreases DHBV transcription but this effect seems to be compensated by an opposite effect on the synthesis of CCC DNA resulting in a global moderate effect on viral replication. Our results also indicate that after division of chronically infected hepatocytes both daughter cells are infected, confirming that liver regeneration is not sufficient to induce CCC DNA eradication as suggested by the lack of effect of some long term anti-HBV therapies.
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Authors
Olivier Schorr, Christelle Borel, Christian Trepo, Fabien Zoulim, Olivier Hantz,