| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3315008 | Journal of Hepatology | 2007 | 8 Pages |
Abstract
In AFP/βGal mice, βGal is a fetal liver self-antigen. Interestingly, the basal tolerance to βGal displayed by these animals is increased during liver re-expression of the self-antigen in adulthood. Adenoviral immunisation allows complete elimination of βGal-expressing hepatocytes in spite of this increased peripheral tolerance. These results highlight the importance of tolerance against self-antigens and validate the AFP/βGal mice as a good background to test immunotherapy strategies in hepatocarcinogenesis models.
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Authors
Jeannette Cany, Audrey Avril, Virginie Pichard, Dominique Aubert, Nicolas Ferry, Sophie Conchon,