Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3315618 | Journal of Hepatology | 2006 | 6 Pages |
Abstract
These findings demonstrate that skeletal muscle adapts, through a rapid induction of glutamine synthetase, to increase its capacity for removal of blood-borne ammonia in acute liver failure. Maintenance of muscle mass together with the development of agents with the capacity to stimulate muscle glutamine synthetase could provide effective ammonia-lowering strategies in this disorder.
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Authors
Nicolas Chatauret, Paul Desjardins, Claudia Zwingmann, Christopher Rose, K.V. Rama Rao, Roger F. Butterworth,