| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3316278 | Pancreatology | 2016 | 9 Pages |
Abstract
The CXCR2 antagonist AZD8309 reduced the transmigration of neutrophils as well as intrapancreatic protease activation in experimental pancreatitis. This effect was sufficient to reduce the overall severity of the disease. CXCR2 may therefore be a viable therapeutic target and AZD8309 a suitable agent for the treatment of acute pancreatitis.
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Authors
Sudarshan R. Malla, Carina Kärrman MÃ¥rdh, Annett Günther, Ujjwal M. Mahajan, Matthias Sendler, Jan D'Haese, Frank Ulrich Weiss, Markus M. Lerch, Mark Berner Hansen, Julia Mayerle,