| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3317407 | Pancreatology | 2012 | 6 Pages |
Abstract
Some studies demonstrated that the Hedgehog-secreted signaling proteins are overexpressed in both the stromal and CSCs pools, implying an abnormal activation of HH in the main compartment of pancreatic cancer. For this reason, the Hedgehog pathway could be an interesting target for clinical trials to increase drug concentration in neoplastic cells and hence deplete the stroma and directly kill tumor-initiating cells.
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Authors
Mariacristina Di Marco, Marina Macchini, Silvia Vecchiarelli, Sokol Sina, Guido Biasco,