Article ID Journal Published Year Pages File Type
3317880 Pancreatology 2012 10 Pages PDF
Abstract
Our data demonstrate that LBH589 induced the death of pancreatic tumor cell by apoptosis. In line with its in vitro activity, LBH589 achieved a significant reduction in tumor growth in BxPC-3 pancreatic tumor cell line subcutaneous xenograft mouse model. Furthermore, exploring the impact of LBH589 on HDACs encoding genes expression revealed for the first time that some of them, depending on the cell line considered, seem to be regulated during translation.
Related Topics
Health Sciences Medicine and Dentistry Gastroenterology
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