Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3317880 | Pancreatology | 2012 | 10 Pages |
Abstract
Our data demonstrate that LBH589 induced the death of pancreatic tumor cell by apoptosis. In line with its in vitro activity, LBH589 achieved a significant reduction in tumor growth in BxPC-3 pancreatic tumor cell line subcutaneous xenograft mouse model. Furthermore, exploring the impact of LBH589 on HDACs encoding genes expression revealed for the first time that some of them, depending on the cell line considered, seem to be regulated during translation.
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Authors
Ouaïssi Mehdi, Silvy Françoise, Costa Lima Sofia, Giger Urs, Zemmour Kevin, Sastre Bernard, Sielezneff Igor, Cordeiro-da-Silva Anabela, Lombardo Dominique, Mas Eric, Ouaïssi Ali,