Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3318532 | Pancreatology | 2006 | 4 Pages |
Abstract
Background and Aims: Chronic pancreatitis (CP) is an inflammatory process initiated by recurrent acute pancreatitis and characterized by progressive parenchyma destruction and fibrosis. Genetic factors influence susceptibility and modify progression. The monocyte chemotactic protein-1 (MCP-1) -2518 G allele, which modifies the severity of acute pancreatitis, was investigated as a susceptibility factor for CP.Methods: A genetic association study was performed on 177 CP patients and 116 healthy controls from the NAPS2 Study. The MCP-1 A/G genotype was determined by RFLP and confirmed by DNA sequencing.Results: Compared to the control group the MCP-1 -2518 genotypes were similar: A/A (57% vs. 50%), A/G (34.5% vs. 40%) and G/G (8.5% vs. 10%). These allele frequencies were not statistically different (p = 0.267).Conclusions: Although the proinflammatory chemokine MCP-1 -2518 G allele is a severity factor for AP, it does not significantly alter susceptibility to CP.
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Authors
David A. Sass, Georgios I. Papachristou, Janette Lamb, M. Michael Barmada, Randall E. Brand, Mary E. Money, Robert H. Hawes, Peter B. Cotton, Adam Slivka, David C. Whitcomb,