Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3319285 | Seminars in Colon and Rectal Surgery | 2014 | 4 Pages |
Abstract
A combination of chemoradiation therapy (CRT) and total mesorectal excision (TME) provides excellent locoregional control in locally advanced rectal cancer; however, this regimen may be associated with significant morbidity. Researchers have assessed the safety of omitting rectal resection in patients who achieve a clinical complete response to CRT. Preliminary results have been promising. However, the accurate identification of patients who have responded completely to CRT is a challenge to non-operative management. Other areas warranting further investigation include techniques to increase response rates and to identify upfront those patients who are most likely to respond to CRT.
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Authors
Sarah A. MD, Karyn A. MD,