| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 331934 | Psychiatry Research | 2013 | 4 Pages |
Abstract
We investigated whether the effect of neonatal hypoxia on amphetamine-induced hyperlocomotion can reproduce the ontogenic (age of onset) properties of schizophrenia. Neonatal hypoxia enhanced amphetamine-induced hyperlocomotion in adult mice and decreased it in adolescent mice. These findings provide ontogenic validity for this very simple animal model of schizophrenia.
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Authors
Sonia R. Kameda, Daniela F. Fukushiro, Raphael Wuo-Silva, Thaís F. Trombin, Roberta Procópio-Souza, Letícia C. Brandão, Leandro Sanday, Camilla L. Patti, Elisa Mári-Kawamoto, Sergio Tufik, Vânia D’Almeida, Roberto Frussa-Filho,