Application of cell sheet technology for esophageal endoscopic submucosal dissection

Because esophageal ulceration is extensive after endoscopic submucosal dissection, we have developed a new treatment that combines endoscopic dissection with the endoscopic transplantation of oral mucosal epithelial cell sheets to prevent esophageal stenosis. Cell sheets created from the patient's own oral mucosa were attached directly to the bed of the esophageal ulcer using endoscopic forceps immediately after endoscopic resection. The first application of regenerative medicine to endoscopic treatment was performed in 2008 and more patients are being accumulated. We are working on several advanced research methods using regenerative medicine for endoscopic treatment.