Myopathies aux statines

Dietary excess of saturated fats and cholesterol accounts for the most common cause of moderate LDL-C elevation, a major and independent predictor of cardiovascular disease-related morbidity and mortality. Among various treatments including diet and pharmacologic therapy affecting various pathways of cholesterol absorption and metabolism, statins are the currently available and most powerful LDL-C lowering agents leading to an effective cardiovascular mortality and morbidity decrease. Statins use is safe but muscular intolerance, a common related-disorder, is a difficult challenge to manage.