Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
332682 | Psychiatry Research | 2006 | 4 Pages |
Abstract
The effects of chronic electroconvulsive shock (ECS), given daily for 1, 5 and 10 days, on the activation of extracellular signal-regulated kinase (ERK) were studied in the rat frontal cortex. The phosphorylation of MEK1/2 and ERK1/2 increased through 5 days of ECS. Thereafter, a plateau was achieved. The expression of brain-derived neurotrophic factor was continuously increased for 10 days. Our data show that the effect of ECS on ERK1/2 signaling is increased with chronic treatment.
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Authors
Ung Gu Kang, Young Jin Koo, Won Je Jeon, Doo Byung Park, Yong Sung Juhnn, Joo Bae Park, Yong Sik Kim,