Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3328147 | Acta Haematologica Polonica | 2013 | 6 Pages |
Abstract
Chemotherapy-induced neutropenia is a major dose-limiting toxicity of systemic cancer chemotherapy and can lead to fever and life-threatening infections. Complications of cytotoxic chemotherapy are more common in older patients than in younger. Prospective trials in older patients with lymphomas or solid tumors have found that age is a risk factor for chemotherapy-induced neutropenia and febrile neutropenia. Granulocyte colony-stimulating factors reduce the duration of neutropenia and its febrile complications, frequency of hospitalization and using of therapeutic antibiotics in patients with hematological malignancies. Prophylaxis of neutropenia with granulocyte colony-stimulating factors makes treatment with optimal-dose chemotherapy possible, especially in the elderly patients.
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Authors
Justyna Dzietczenia,