Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3328362 | Acta Haematologica Polonica | 2013 | 7 Pages |
Abstract
In this study we assessed homocysteine level in 106 patients with ET - 80 females and 26 males, mean age 54 (23-82) and in 20 healthy persons - 6 males and 14 females, mean age 41 (31-54). We also searched for a relation between homocysteine level and MTHFR gene mutation as well as vitamin B12 and folic acid concentration. Median homocysteine serum level was higher in ET patients than in control group. Elevated homocysteine level primarily stems from folic acid deficiency rather than from the presence of MTHFR gene mutation. Median folic acid level was lower in ET patients presenting thrombotic and bleeding complications than in ET patient without vascular episodes. We concluded that folic acid substitution may not only prevent hyperhomocysteinemia but also the development of vascular complications in ET patients.
Keywords
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Bożena SokoÅowska, Ksenia Bykowska, Ewa Mendek-Czajkowska, Aleksandra NowaczyÅska, Adam Walter-Croneck, Tomasz Gromek, Anna M. Kowalska, Sylwia Chocholska, Katarzyna Wejksza, Martyna Kandefer-SzerszeÅ, Adam SokoÅowski, Jerzy Windyga,