Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3328482 | Acta Haematologica Polonica | 2012 | 6 Pages |
Abstract
Antibodies against human leukocyte antigen (anti-HLA Abs) are important factors responsible for graft rejection in solid organ transplantation, but their role in allogeneic hematopoietic stem cell transplantation (allo-HSCT) is unknown. As the number of patients who are treated with HLA-mismatched HSCT (including cord blood, haploidentical and unrelated HSCTs) constantly increases, the presence and influence of anti-HLA antibodies on the HSCT outcome is unknown. Thus we have examined incidence and influence of anti-HLA antibodies on outcomes of allo-HSCT from HLAmismatched unrelated donors. Abs were identified in sera collected from 30 recipients. We have used automated DynaChip assay which uses microchips bearing purified class I and II HLA antigens for detection of anti-HLA Abs. The preliminary results indicate that anti-HLA Abs appear post transplant in mismatched allo-HSCT recipients and may be potentially responsible for the occurrence of post-transplant complications.
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Authors
Anna KoclÄga, MirosÅaw Markiewicz, Urszula Siekiera, Alicja Dobrowolska, Monika Dzierżak-MietÅa, Sylwia Mizia, Patrycja ZieliÅska, MaÅgorzata Kopera, SÅawomira Kyrcz-KrzemieÅ,