| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3328497 | Acta Haematologica Polonica | 2012 | 7 Pages |
Abstract
By the means of Real Time PCR we studied IL-6 expression on mRNA level (RQ) in B-CLL lymphocytes and in CD19Â + subpopulation of normal B lymphocytes before and after 30 min and 24h LPS stimulation. The IL-6 expression level (RQ) in B-CLL cells was significantly lower (p=0.00348) compared with the subpopulation of CD19Â + normal lymphocytes. 30 min LPS stimulation resulted in increase of IL6 mRNA expression, both in normal and B-CLL lymphocytes. IL6 mRNA expression level decreased after 24h LPS stimulation (p=0.012970) in normal lymphocytes, whereas B-CLL cells showed constant increase (p=0.000001). These data seem to indicate an aberrant endotoxin tolerance in B-CLL.
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Authors
Halina Antosz, Joanna Sajewicz, Barbara Marzec-Kotarska, Dorota ChoroszyÅska, Anna DmoszyÅska,