TP53 dysfunction in diffuse large B-cell lymphoma

•In this work, we systematically reviewed recent advances on different mechanisms of TP53 in DLBCL including the following aspects.•miRNA regulations and novel single nucleotide variants which influence it.•Copy number aberrant of TP53 pathway and TP53 itself and dysregulation of TP53 regulators.•MDM2 and other posttranslational modifications on TP53 and clinical trials targeting MDM2 and TP53 interaction or restoring the activity of mutantp53 and so on.•Somatic mutations by abnormal TP53 function modes.•The role of TP53 and its isoforms in normal function and tumorigenesis, the function of TP53 in immune and inflammatory response metabolism which are also important in oncogenesis including lymphma.•TP53 and autophagy which promotes survival of lymphoma cells.

The aberrations of TP53 gene and dysregulation of the TP53 pathway are important in the pathogenesis of many human cancers, including malignant lymphomas, especially for diffuse large B cell lymphoma (DLBCL). By regulating many downstream target genes or molecules, TP53 governs major defenses against tumor growth and promotes cellular DNA repair, apoptosis, autophagy, cell cycle arrest, signaling, transcription, immune or inflammatory responses and metabolism. Dysfunction of TP53, including microRNA regulations, copy number alterations of TP53 pathway and TP53 itself, dysregulation of TP53 regulators, and somatic mutations by abnormal TP53 function modes, play an important role in lymphoma generation, progression and invasion. The role of TP53 in DLBCL has been widely explored recently. In this review, we summarized recent advances on different mechanisms of TP53 in DLBCL and new therapeutic approaches to overcome TP53 inactivation.