Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3328666 | Critical Reviews in Oncology/Hematology | 2015 | 17 Pages |
•We reviewed 18 clinical trials enroling 13,958 patients with colorectal cancer.•We compared standard therapies with those therapies plus cetuximab or panitumumab.•We assessed risk of severe diarrhea and mucositis in intervention and control groups.•We found an increased risk in patients receiving Cetuximab or panitumumab.•Adopting risk reduction strategies to limit impact of these AEs is needed.
The anti-Epidermal Growth Factor Receptor monoclonal antibodies (anti-EGFR MoAbs) are beneficial in the treatment of wild type (WT) KRAS colorectal cancer, but are burdened by serious toxicities. We conducted a systematic review and meta-analysis to determine incidence and relative risk (RR) of severe and life-threatening diarrhoea and mucositis in colorectal cancer patients and WT-KRAS subpopulation.PubMed and Embase were searched for trials comparing the same therapeutic regimens with or without anti-EGFR for colorectal cancer. Data on severe and life-threatening diarrhoea and mucositis were extracted from 18 studies involving 13,382 patients. Statistical analyses calculated incidence of AEs, RRs and 95% confidence intervals by using either random or fixed effects models. Patients receiving anti-EGFR MoAbs showed an increased risk of diarrhoea (RR: 1.66, CI 1.52–1.80) and mucositis (RR: 3.44, CI 2.66–4.44). The risk was similar among WT-KRAS patients. Prevention and risk reduction strategies of these AEs are mandatory to optimize clinical outcomes.