Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3329920 | Critical Reviews in Oncology/Hematology | 2008 | 10 Pages |
Abstract
Venous thromboembolism is an important clinical problem. Cancer patients have higher risk to develop venous thrombosis and vice versa. The treatment consists of heparin followed by vitamin K antagonists. Both agents have several limitations. Especially in cancer patients, vitamin K antagonists cause bleeding or recurrence of VTE because of a small therapeutic window. Monotherapy with low-molecular weight heparin seems to cause less of these complications in cancer patients compared to vitamin K antagonists. Besides, the drug is thought to have anti-cancer properties. Several novel anticoagulants are being developed and are undergoing clinical evaluation. New anticoagulants should also be evaluated on the effect on progression of cancer and cancer-related survival.
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Authors
F.F. van Doormaal, H.R. Büller, S. Middeldorp,