World Health Organization and Beyond: New Aspects in the Pathology of an Old Disease

Hodgkin's lymphoma is a highly enigmatic lymphoma disease that still covers most of its secrets up to now. Much effort has been made to successfully wrest at least some of the pathogenetic particularities. The current diagnostic criteria are well established allowing hematopathologists to make a clear-cut distinction from other lymphomas in almost all cases. Although classic Hodgkin's lymphoma is curable in the vast majority of cases by treatment with highly aggressive drugs with or without radiotherapy, further molecular studies may lead to the identification of therapeutic targets that enable a more tailored treatment with fewer side effects.