| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3331946 | Hematology/Oncology Clinics of North America | 2009 | 14 Pages |
Abstract
This article discusses the etiology of paroxysmal nocturnal hemoglobinuria (PNH) and its relationship to marrow hyperplasia. The author posits that the defining clinical pathology of PNH (ie, complementmediated intravascular hemolysis) is an epiphenomenon that is a consequence of an orchestrated response (ie, natural selection of PIGA-mutant stem cells) to a specific type of bone marrow injury (ie, immune mediated). Management of PNH is discussed also.
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Authors
Charles J. Parker,