Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3331948 | Hematology/Oncology Clinics of North America | 2009 | 16 Pages |
Abstract
Patients who have acquired and inherited bone marrow failure syndromes are at risk for the development of clonal neoplasms including acute myeloid leukemia, myelodysplastic syndrome, and paroxysmal nocturnal hemoglobinuria. This article reviews the evidence supporting a model of clonal selection, a paradigm that provides a reasonable expectation that these often fatal complications might be prevented in the future.
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Authors
Grover C. Bagby, Gabrielle Meyers,