Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3332181 | Hematology/Oncology Clinics of North America | 2008 | 13 Pages |
Abstract
Constitutional (hereditary) genetic variation and somatic genetic alterations acquired during transformation to the neoplastic phenotype are both critical determinants of cancer outcome, and can ultimately have a significant effect on cancer survivorship. This article discusses the role of constitutional and somatic genetics in determining outcome and survivorship following a diagnosis of cancer using illustrative examples primarily from the hematologic malignancies.
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Authors
James M. Allan,