Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3333660 | Seminars in Hematology | 2012 | 11 Pages |
Abstract
Female long-term survivors of allogeneic hematopoietic stem cell transplantation (allo-HSCT) incur a significant burden of late effects. Genital graft-versus-host disease (GVHD), human papillomavirus (HPV) reactivation, ovarian failure and infertility, sexual dysfunction, and osteoporosis are concerns that can significantly impact quality of life. This review examines the risk, pathogenesis, clinical presentation, and implications of these common complications. Recommendations are provided for evaluation and management of these late effects and other obstetric and gynecologic issues that may arise in this patient population.
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Authors
Dana Shanis, Melissa Merideth, Tajana Klepac Pulanic, Bipin N. Savani, Minoo Battiwalla, Pamela Stratton,