Article ID Journal Published Year Pages File Type
3334162 Seminars in Hematology 2008 6 Pages PDF
Abstract

Observational studies have consistently documented independent, strong associations of anemia—even if not severe—with major adverse functional outcomes in older adults. In this chapter, recent epidemiologic evidence linking mild anemia with decline in physical and cognitive function, frailty, and disability in community-dwelling older adults is reviewed. Altogether, these biologically plausible associations provide empirical, though not conclusive, support for the notion of mild anemia as a cause of adverse functional outcomes in older adults. Randomized clinical trial data assessing the impact of anemia correction on functional outcomes are lacking at this time.

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