Ascending Infection

Acute chorioamnionitis is a major cause of spontaneous preterm birth, accounting for more than 40% of deliveries complicated by preterm premature rupture of membranes or preterm labor. In the majority of cases, especially in preterm births, acute chorioamnionitis is caused by ascending polymicrobial infection. Recent evidence suggests that in some cases acute chorioamnionitis may have a noninfectious cause. In addition to the nonspecific patterns of conventional acute chorioamnionitis, this article describes characteristic inflammatory patterns indicative of a specific infectious cause. Several inflammatory entities of putative immunologic (noninfectious) etiology are addressed, including eosinophilic/T-cell vasculitis and chronic chorioamnionitis.