Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3334505 | Surgical Pathology Clinics | 2015 | 9 Pages |
Abstract
The pilocytic astrocytoma is predominantly a tumor of childhood and the most common type of circumscribed astrocytoma. The indolent nature of this tumor allows for prolonged survival for most patients, rendering the disease a rather “chronic” one, with potential long-term sequelae that are occasionally related to treatment. Two critical features of this tumor are its tendency to remain dormant, or involute even after subtotal resection, and the exceptional anaplastic transformation, sometimes following adjuvant therapy. The biological behavior of pilocytic astrocytoma can often be related to molecular alterations in the MAPK pathway.
Keywords
Related Topics
Health Sciences
Medicine and Dentistry
Hematology
Authors
Gerald F. Reis, Tarik Tihan,