Older age and capacity of colony forming unit in autologous peripheral derived hematopoietic cells

BackgroundAging decreases bone marrow cellularity and alters the frequencies of stem cells. Aged hematopoietic stem cells can differ from their younger counterparts in functional capacity.Study design and methodsWe aimed to evaluate the relation between the age and the ability of colony forming capacity of peripheral blood-derived hematopoietic cell products collected for autologous stem cell transplantation (AHSCT).ResultsElderly patients could be mobilized with lower total collected CD34+ cells. Colony forming capacity did not differ between young and old patients.ConclusionThis results can be translated into clinic as higher numbers of AHSCT candidates over age 60.