Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3335381 | Transfusion and Apheresis Science | 2012 | 6 Pages |
Abstract
We report the death of a 61-year-old Japanese man massively transfused during and after emergency aortic surgery. Postoperative on day 8, he died after cardiac arrest associated with hyperkalemia. Indirect antiglobulin testing demonstrated both anti-Dib and anti-E antibodies pre-transfusion, and elevation of their titers as the delayed hemolytic transfusion reaction evolved. Monocyte monolayer assay (induction of reactive monocytes) and flow cytometry (increase of IgG1 and/or IgG3) gave evidence of the clinical significance of both antibodies. Anti-Dib must be considered when an antibody to a high incidence antigen is found in Japanese and other Mongoloid populations.
Keywords
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Authors
Yuichiro Hatano, Setsuko Otsuka, Mitsuhiro Chousa, Shunnichi Saito, Kenneth E. Nollet, Hitoshi Ohto, Katsuya Shimabukuro, Hirofumi Takemura, Akira Hara,