The efficacy of erythrocytes isolated from blood stored under blood bank conditions

BackgroundThe RBCs storage lesion is most carefully viewed as the sum of all the changes in RBCs occurring during the course of storage and that limit their survival.Materials and methodsErythrocytes were isolated from stored blood at regular intervals. Oxidative stress markers were analyzed to determine the changes during the storage.ResultsAntioxidant enzymes – (SOD and CAT), and SH showed insignificant variation whereas hemolysis, MDA and AOPP showed significant variations.ConclusionThe oxidative stress has not successfully overridden the protection offered by the endogenous antioxidant system. Prolonged storage may result in the onset of erythrocyte deterioration. This clearly indicates that the erythrocytes are capable of attenuating ROS with 2 weeks of storage.