| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3335445 | Transfusion and Apheresis Science | 2012 | 5 Pages |
Abstract
The aim of our study is to assess the mortality of leukocytes during extracorporeal photopheresis. Sixty-three photopheresis performed on 13 patients affected by chronic GvHD were evaluated. Samples were analyzed using a FACSCalibur flow cytometer. Apoptosis and necrosis of limphomononuclear cells dramatically increased after the apheretic procedure. We found a further increase of apoptotic and necrotic limphomononuclear cells after treatment with 8-MOP and UVA (p ⩽ 0.05). Our data suggested that the immunomodulatory effects of extracorporeal photopheresis, triggered by circulating apoptotic or necrotic cells, could play an important role in the treatment of GvHD with this procedure.
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Authors
Nicola Daniele, Gianpaolo Del Proposto, Paola Cerrone, Silvia Sinopoli, Lucia Sansone, Deborah Ilaria Gadaleta, Alessandro Lanti, Angelo Salvatore Ferraro, Stefano Spurio, Maria Cristina Scerpa, Francesco Zinno, Gaspare Adorno, Giancarlo Isacchi,