Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3335602 | Transfusion and Apheresis Science | 2013 | 4 Pages |
Abstract
A 70 year old Caucasian woman with IgG lamda multiple myeloma presented with uncontrollable bleeding from a bone marrow biopsy site which started days after the procedure. The patient was hyperviscous, and coagulation tests showed elevated activated partial thromboplastin time (aPTT) which was not corrected with a mixing study, elevated thrombin time and reptilase time, and possible inhibitors to Factors VIII and IX. Therapeutic plasma exchange was performed using plasma with corrections of plasma viscosity (1.6 to 1.1 centipoise) and aPTT (50 to 42.1 s) observed. The bleeding was controlled, and purified IgG demonstrated dysfibrinogenemic effects of the patient’s paraprotein.
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Authors
Ginell R. Post, Lindsey James, Daisy Alapat, Virginia Guillory, Michele Cottler-Fox, Mayumi Nakagawa,