Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3335752 | Transfusion and Apheresis Science | 2011 | 7 Pages |
Abstract
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is caused by maternal antibodies that cross the placenta in connection with pregnancy and destroy fetal platelets. Recently, maternal T cell responses associated with FNAIT have been studied at the clonal level. These T cell clones recognize an integrin β3 epitope, which is anchored to the HLA-DRB3∗0101-encoded MHC molecule DR52a. The same MHC allele is strongly associated with FNAIT. As the production of pathological antibodies reactive with fetal platelets is likely dependent on these T cell responses, there exists a potential for preventing FNAIT by targeting these T cells.
Keywords
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Authors
Tor B. Stuge, Bjørn Skogen, Maria Therese Ahlen, Anne Husebekk, Stanislaw J. Urbaniak, Hagop Bessos,