Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3336102 | Transfusion and Apheresis Science | 2009 | 5 Pages |
Abstract
The present study compared the effects of direct hemoperfusion (DHP) using a cytokine absorbing (CTR) column with those using an endotoxin absorbing (PMX) column with endotoxin-induced shock in rats. Thirty-six rats were injected intravenously with endotoxin (15 mg/kg), and then allocated into one of the following three groups: control group, treated without CTR; PMX group, treated with a PMX column for 120 min; CTR group, treated with a CTR column for 120 min. The present study showed that CTR treatment decreased the mortality rate 8 h after endotoxin injection and inhibited inflammatory responses (cytokine, hemodynamics and acidosis) similar to PMX treatment.
Keywords
Related Topics
Health Sciences
Medicine and Dentistry
Hematology
Authors
Takumi Taniguchi, Akihide Kurita, Ken Yamamoto, Hideo Inaba,