Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3336161 | Transfusion and Apheresis Science | 2007 | 7 Pages |
Abstract
We performed an 11 year retrospective study on 34 sickle-cell paediatric patients, focusing on efficacy, safety and costs of an exchange transfusion program in 13 high risk patients.A good clinical control with improvement in patients’ quality of life, no disease related complications, no significant iron overload and no procedure related side effects were observed during periodic erythroexchange. Costs of periodic erythroexchange versus chronic transfusion regimen were comparable. Periodic erythroexchange appeared a good alternative to chronic transfusion regimen for controlling the most severe forms of disease, particularly in patients who do not tolerate or do not respond to hydroxyurea.
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Authors
Nicoletta Masera, Luisa Tavecchia, Lorena Pozzi, Francesca Riva, Chiara Vimercati, Manuela Calabria, Simona Ronzoni, Giuseppe Masera, Paolo Perseghin,