Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3336535 | Transfusion Medicine Reviews | 2012 | 16 Pages |
Abstract
Transfusion-related acute lung injury (TRALI) is a major cause of transfusion-related morbidity and mortality. Although the pathogenesis of TRALI is incompletely understood, substantial data from hemovigilance systems, large case series, clinical trials, and animal models have identified antileukocyte antibodies as a major precipitant and have contributed to the development of concrete interventions to reduce the risk of TRALI. This review presents the clinical data supporting specific donor management strategies to reduce TRALI risk and their observed clinical efficacy. Novel strategies that use the donor health questionnaire combined with testing are discussed, and important challenges that remain going forward are explored.
Related Topics
Health Sciences
Medicine and Dentistry
Hematology
Authors
Robert S. Makar, Amy Powers, Christopher P. Stowell,