Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
333713 | Psychiatry Research | 2011 | 4 Pages |
Abstract
Genetic factors play an important role in the understanding of clinical response to antipsychotic treatments. We aimed to assess the effect of the catechol-O-methyltransferase (COMT) genotype in the short-term (6 weeks) clinical response of 161 first-episode psychosis patients. COMT genotype was not related to clinical response at 6 weeks. Val homozygote patients showed higher negative symptoms than Met homozygote patients. The COMT Val158 genotype seems to be related to the severity of negative symptoms rather than to clinical response.
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Authors
José María Pelayo-Terán, Rocío Pérez-Iglesias, Javier Vázquez-Bourgon, Ignacio Mata, Eugenio Carrasco-Marín, José Luis Vázquez-Barquero, Benedicto Crespo-Facorro,