Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3339736 | Allergologia et Immunopathologia | 2014 | 7 Pages |
BackgroundAtaxia-telangiectasia (A-T) is a rare and degenerative disease that leads to varying degrees of immunodeficiency, oxidative stress, and malnutrition. Vitamin A and zinc are essential for immune function and antioxidant defence.ObjectiveTo compare levels of retinol, beta carotene, and zinc in patients with ataxia-telangiectasia and healthy controls.MethodsWe performed a cross-sectional study with 14 AT patients and 14 healthy controls matched for age and gender. All participants underwent a nutritional and laboratory evaluation comprising concentrations of retinol, beta carotene, serum and erythrocyte zinc, malondialdehyde (MDA), T lymphocyte numbers (CD4+ and CD8+) and immunoglobulin (IgA).ResultsThe AT patients showed high rates of malnutrition with reduced lean body mass when compared to the control group. However, the concentrations of MDA, retinol, beta carotene, and serum and erythrocyte zinc in AT patients were similar to those of the control group. The retinol levels presented a negative correlation with MDA and positive correlation with IgA serum level.ConclusionsThe AT patients assessed showed no change in nutritional status for vitamin A and zinc; however, they presented severe impairment in overall nutritional status observed and correlation between retinol with MDA and IgA.