Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3340329 | Allergologia et Immunopathologia | 2007 | 9 Pages |
Abstract
Gene therapy. Patients with PID are ideal candidates, as they are monogenic, the haematopoietic cells are easily obtained and virus replication is easy within them. Vectors (viruses) “infect” the stem cells of the patient's bone marrow, producing the transfection of the wild (healthy) gene in these cells. Encouraging results have been achieved in X-linked SCID as there are a number of patients who are considered “cured”, although neoplastic processes have occurred due to the activation of proto-oncogenes close to the point of insertion of the external gene, using retroviruses as vectors; there are now trials with adenovirus, physical methods (direct injectionâ¦) and chemical methods (viral modification, artificial virusesâ¦). Gene therapy has also been performed in patients with Chronic Granulomatous Disease and trials will improve in the future with changes in protocols used in oncology and infectious diseases.
Keywords
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Authors
J.M. GarcÃa, T. Español, M.ªD. Gurbindo, C. Casas C,