Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3341291 | Autoimmunity Reviews | 2016 | 6 Pages |
Abstract
TGF-β family members are multipotent cytokines that are involved in many cellular processes, including cell differentiation, organ development, wound healing and immune regulation. TGF-β has pleiotropic effects on adaptive immunity, especially in the regulation of CD4+ T cell and B cell responses. Furthermore, identification of CD4+ T cell subsets that produce TGF-β3 revealed unexpected roles of TGF-β3 in the control of adaptive immunity. In contrast to TGF-β1, which induces extensive fibrosis, TGF-β3 induces non-scarring wound healing and counteracts tissue fibrosis. Recent progress in the understanding of the activation mechanism of TGF-β may enable us to develop novel biologic therapies based on advanced protein engineering.
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Authors
Keshi Fujio, Toshihiko Komai, Mariko Inoue, Kaoru Morita, Tomohisa Okamura, Kauzhiko Yamamoto,