Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3341415 | Autoimmunity Reviews | 2015 | 7 Pages |
Abstract
Regulatory T cells (Tregs) are essential in maintaining tolerance to self. Several lines of evidence indicate that Tregs are functionally impaired in a variety of autoimmune diseases, leading to inefficient regulation of autoimmune T cells. Recent findings also suggest that Tregs are essential in controlling autoreactive B cells. The recently identified follicular regulatory T cell subset (TFR) is thought to regulate the production of autoantibodies in the germinal center (GC) response. Here we provide an update on the role of Tregs in controlling the GC response, and whether defective control over B cell tolerance contributes to autoimmunity.
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Authors
Tessa Dhaeze, Piet Stinissen, Adrian Liston, Niels Hellings,