| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3341830 | Autoimmunity Reviews | 2011 | 7 Pages |
Abstract
A group of primary vasculitides is associated with the presence of anti-neutrophil cytoplasmic autoantibodies (ANCA). In these diseases, the contribution of ANCA to disease pathogenesis has been studied extensively. Also, in patients with ANCA-associated vasculitides, the T lymphocyte compartment is dysregulated, as aberrant distribution and function of T cell subsets has been shown. In this review we will discuss the putative role of T lymphocytes in inflammation and granuloma formation, as well as the involvement of B cell compartments in the pathophysiology of ANCA-associated vasculitis.
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Authors
Nikola Lepse, Wayel H. Abdulahad, Cees G.M. Kallenberg, Peter Heeringa,