| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3341930 | Autoimmunity Reviews | 2011 | 5 Pages |
Refractory vasculitis occurs in 4–5% of patients with anti-neutrophil cytoplasmic antibody associated vasculitis (AAV). Differences between therapies used for refractory disease are mostly reflected in the percentages of complete and partial remissions, but also in the number of serious side effects. Rituximab is considered the most safe second line therapy and should be advocated as a first alternative choice for cyclophosphamide in disease induction in refractory AAV.
► Refractory vasculitis is a major cause of death in vasculitic disease ► Therapeutic options for refractory vasculitis are expanding ► Rituximab is a promising treatment modality for refractory ANCA associated vasculitis ► Clinical trials are needed to enable evidence based treatment decisions.
