| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3342183 | Autoimmunity Reviews | 2010 | 4 Pages |
Abstract
Anti-Ku antibodies are reported in various connective tissue diseases and the Ku complex can be responsible for a very strong autoimmune answer in autoimmune disease. Nowadays, anti-Ku antibodies are detected by ELISA, counterimmunoelectrophoresis (CIE), immunoblot (IB) and new highly performant techniques.Although the prevalence of anti-Ku antibodies is not homogenous, depending on several features such as disease type, genetic and geographical clustering, and also method of detection, they could be found in 55% overlap PM/systemic sclerosis patients.Moreover, anti-Ku antibodies are not associated with a particular clinical outcome, and especially with cancer related to myositis.
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
C. Belizna, D. Henrion, A. Beucher, C. Lavigne, A. Ghaali, H. Lévesque,