Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3342248 | Autoimmunity Reviews | 2009 | 5 Pages |
Abstract
While the involvement of T cells in atherosclerosis is nowadays well accepted, little is known about the role of B cells. Obviously, B cells as the source of antibodies, in particular antibodies to oxLDL, have gained a lot of attention in atherosclerosis. In addition, B cells do harbour other functions in adaptive immunity. In this review, we provide an overview of the current knowledge on both the role of B cells and antibodies, i.e., anti-oxLDL antibodies, in atherosclerosis. It appears that B cells and also anti-oxLDL antibodies may comprise pro- and anti-atherogenic effects. Therefore, the establishment of effective therapy, targeting B cells or anti-oxLDL antibodies, warrants further research to unravel these opposite effects.
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Authors
M. van Leeuwen, J. Damoiseaux, A. Duijvestijn, J.W. Cohen Tervaert,