Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3342254 | Autoimmunity Reviews | 2009 | 4 Pages |
Abstract
The development of specific therapies for organ-specific autoimmune diseases requires the identification of relevant immunogenic epitopes, recognized by both pathogenic T cells and autoantibodies.Here, we review the most relevant studies focused in the identification of peptides in multiple sclerosis (MS) and the distinct T cell reactivity induced in patients compared to controls. Only a few studies reported significant differences in terms of T cell reactivity to them. The current knowledge on this issue, and the diagnostic and therapeutic possibilities opened by the identification of pathogenic MS epitopes are discussed in this paper.
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Authors
L. Grau-López, D. Raïch, C. Ramo-Tello, M. Naranjo-Gómez, A. Dàvalos, R. Pujol-Borrell, F.E. Borràs, E. Martínez-Cáceres,