| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3342416 | Autoimmunity Reviews | 2007 | 6 Pages |
Abstract
We cloned the SLAM associated protein (SAP) gene in 1995. In 1998, it was discovered that the SAP gene was defective in patients with X-linked lymphoproliferative disease. Subsequently, details on the key role of life-long immune memory (vaccination) and of life-long autoantibody production in patients suffering from autoimmune disease have been revealed. In this paper, we discuss the dual nature of SAP in humans: its beneficial effect on life-long immune memory (vaccination) and its harmful effect on life-long autoantibody production.
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Authors
Shigemasa Sawada, Masami Takei, Tetsuyosi Ishiwata,