Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3342754 | Autoimmunity Reviews | 2006 | 4 Pages |
Abstract
Common variable immune deficiency (CVID) is associated with autoimmune and inflammatory complications in addition to recurrent infections. The most common conditions are idiopathic thrombocytopenia purpura, autoimmune hemolytic anemia, sarcoid-like granulomatous disease and gastrointestinal inflammation. IVIG administration reduces the frequency of infections, but does not always prevent autoimmunity or inflammation. TNF antagonists and anti-CD20 immunomodulators have shown some efficacy in CVID in a few patients; further controlled studies are needed to determine the best management of these conditions in the setting of immunodeficiency.
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Authors
Adina Kay Knight, Charlotte Cunningham-Rundles,