| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 334417 | Psychiatry Research: Neuroimaging | 2015 | 7 Pages |
•FA measures of white matter showed linear relationship with ADHD symptom severity.•RD measures of white matter showed linear relationship with ADHD symptom severity.•RD in superior longitudinal fasciculus was linked to Inattentive symptoms.•RD in superior longitudinal fasciculus not linked to Hyperactivity/Impulsivity symptoms.
The present study sought to evaluate whether white matter microstructure abnormalities observed in a cohort of adolescents with attention-deficit/hyperactivity disorder (ADHD) have specific relationships with either or both Hyperactivity/Impulsivity and Inattentive ADHD symptom domains that would support a dimensional view of ADHD as adopted in the DSM-V. Diffusion tensor imaging (DTI) data were acquired on 22 adolescents diagnosed with ADHD. Multiple regression analyses were performed to determine whether scalar DTI measures in 13 tracts-of-interest demonstrated meaningful associations with Hyperactivity/Impulsivity or Inattentive symptom severity. Fractional anisotropy and radial diffusivity measures of white matter integrity exhibited significant linear relationships with Hyperactivity/Impulsivity and Inattentive symptom severity. However, only radial diffusivity in the right superior longitudinal fasciculus was specifically linked to Inattentive symptom severity and not Hyperactivity/Impulsivity symptom severity. Our results provide preliminary evidence that symptom domains in ADHD are linked to neuroanatomical substrates and confirm the value in examining ADHD from a dimensional perspective.
