LFA-1 and associated diseases: The dark side of a receptor

Lymphocyte function-associated antigen-1 (LFA-1, αLβ2, CD11a/CD18) plays a critical role in the complex and well-orchestrated molecular interactions responsible for cell adhesion events required for normal and pathologic functions of the immune system. This review focuses on the diseases from various etiologies (genetic, bacterial, viral, neoplastic, allergic, and autoimmune) that are associated to lymphocyte function-associated antigen-1 with a tremendous impact on human and animal health.